Depression is the most common misdiagnosis for someone with bipolar disorder, at about 60%. The general criteria for depression are as follows: depressed mood most of the day, almost every day, markedly decreased interest or pleasure in all or almost all activities most of the day, almost every day, significant weight loss when not dieting or weight gain, decreased or increased appetite almost every day. There are few categories of depression, based on severity of symptoms, duration, and other factors. Below is a description of minor and major depression that may be useful to understand in the context of bipolar disorder.

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Furthermore, depression can be a problem for people who do not have bipolar disorder as well. But while depression can usually be linked to a life event, it doesn't have to be for someone with bipolar disorder. Also, people who suffer from depression do not necessarily appear to be sad all the time when they are at work or hanging out with friends. Depression is not something that is necessarily obvious to everyone, even those who suffer from it. We never really know what might be behind the smiles of the people we see every day, let alone the acquaintances we rarely meet. Sometimes people who are depressed don't want to draw attention to their mental state, so they put on an act to avoid discussion. Checking on your friend, co-worker, family member or acquaintance is free and could very well save a life.